Sodium Bicarbonate → HCID 131714146, compound

HRID 2164238Notes

Reaction equation

HRID 2164238 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([CH2:20][C:21]([OH:30])([P:26]([OH:29])(=[O:28])[OH:27])P(O)(=O)O)=[N:10][N:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:12]=2)=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+:35]>CN(C)C=O.O>[Na+:35].[Na+:35].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([CH:20]([P:26]([OH:29])(=[O:27])[OH:28])[CH:21]([OH:30])[P:26]([O-:27])(=[O:28])[O-:29])=[N:10][N:11]([C:13]3[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=3)[CH:12]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 13177906HCID 13177906, compound

Product 1

HCID 131714146HCID 131714146, compoundYield 154.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 1.9 g of 2-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]-1-hydroxyethane-1,1-diphosphonic acid in 5 ml of dimethylformamide is combined with a solution of 0.8 g of sodium bicarbonate in 10 ml of water and stirred for 2 hours at room temperature. Then the thus-precipitated product is vacuum-filtered, washed with a small amount of water, and dried at 110° C., yielding 1.6 g (76%) of 2-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]-1-hydroxyethanediphosphonic acid disodium salt, mp above 300° C.

Workup

  1. filtrationThen the thus-precipitated product is vacuum-filtered
  2. washwashed with a small amount of water
  3. customdried at 110° C.

Sources & evidence

ORD record
ord-a20f0b84f0d7481ba9b116ec9f3c5053
Source dataset
uspto-grants-1985_03
Patent number
US04503049

Reaction notes

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