HCID 13341893, compound → 3-[4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]propanoic acid

HRID 2164239Notes

Reaction equation

HRID 2164239 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([CH2:20][CH:21](C(O)=O)[C:22]([OH:24])=[O:23])=[N:10][N:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:12]=2)=[CH:4][CH:3]=1>ClC1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[N:10][N:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[CH:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 13341893HCID 13341893, compound

Product 1

HCID 133418943-[4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]propanoic acidYield 82.7%

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A solution of 3 g of [4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolylmethyl]malonic acid in 50 ml of chlorobenzene is heated under reflux until the release of gas ceases (about 2.5 hours). The mixture is concentrated under vacuum, the residue is recrystallized from carbon tetrachloride, thus obtaining 2.2 g of 3-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]propionic acid, mp 131° C.

Workup

  1. temperatureunder reflux until the release of gas ceases (about 2.5 hours)
  2. concentrationThe mixture is concentrated under vacuum
  3. customthe residue is recrystallized from carbon tetrachloride

Sources & evidence

ORD record
ord-61d4f507a0e248c59d351f4b7b26777b
Source dataset
uspto-grants-1985_03
Patent number
US04503049

Reaction notes

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