HCID 13341893, compound → 3-[4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]propanoic acid

Participants

Reaction Steps

A solution of 3 g of [4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolylmethyl]malonic acid in 50 ml of chlorobenzene is heated under reflux until the release of gas ceases (about 2.5 hours). The mixture is concentrated under vacuum, the residue is recrystallized from carbon tetrachloride, thus obtaining 2.2 g of 3-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]propionic acid, mp 131° C.

Provenance & Evidence