Phosphorus pentachloride → HCID 13341895, compound

HRID 2164240Notes

Reaction equation

HRID 2164240 reaction equation
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15]([CH2:26][CH2:27][C:28]([OH:30])=O)=[N:16][N:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH:18]=2)=[CH:10][CH:9]=1>C(OCC)C>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15]([CH2:26][CH2:27][C:28]([Cl:2])=[O:30])=[N:16][N:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH:18]=2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 133418943-[4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]propanoic acid

Product 1

HCID 13341895HCID 13341895, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

At 0° C., 1.3 g of phosphorus pentachloride is added in incremental portions to a mixture of 1.9 g of 3-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]propionic acid in 60 ml of diethyl ether; the mixture is agitated for 3 hours, then concentrated, and the residue recrystallized from petroleum ether, thus obtaining 1.85 g of 3-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]propionic acid chloride, mp 111° C.

Workup

  1. concentrationconcentrated
  2. customthe residue recrystallized from petroleum ether

Sources & evidence

ORD record
ord-0f89f9e4cd594853afc17078289e0f34
Source dataset
uspto-grants-1985_03
Patent number
US04503049

Reaction notes

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