HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → HCID 13341895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 3-[4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]propanoic acid | HCID 13341894 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 13341895 | HCID 13341895 | 92.4% |
Reaction Steps
At 0° C., 1.3 g of phosphorus pentachloride is added in incremental portions to a mixture of 1.9 g of 3-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]propionic acid in 60 ml of diethyl ether; the mixture is agitated for 3 hours, then concentrated, and the residue recrystallized from petroleum ether, thus obtaining 1.85 g of 3-[4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolyl]propionic acid chloride, mp 111° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04503049 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-0f89f9e4cd594853afc17078289e0f34 |
| Source note | uspto-grants-1985_03 |