Hydrochloric Acid → HCID 13394292, compound

Participants

Reaction Steps

A solution of 18.8 g (0.06 mole) of 2-amino-5-methyl-3-[4-(methylthio)benzoyl]phenylacetamide in 1700 ml of absolute ethanol with 16.6 ml (0.2 mol) of concentrated hydrochloric acid was heated at reflux for 45 min. The mixture was diluted with 50 ml of water and cooled. The precipitate was collected and recrystallized from 60% aqueous ethanol to give 11.0 g (62%) of the titled compound as tan crystals, m.p. 176.0°-177.5° C.

Provenance & Evidence