Hydrochloric Acid → HCID 13394292, compound

HRID 2164310Notes

Reaction equation

HRID 2164310 reaction equation
N[C:2]1[C:7]([C:8](=[O:17])[C:9]2[CH:14]=[CH:13][C:12]([S:15][CH3:16])=[CH:11][CH:10]=2)=[CH:6][C:5]([CH3:18])=[CH:4][C:3]=1[CH2:19][C:20]([NH2:22])=[O:21].Cl>C(O)C.O>[CH3:18][C:5]1[CH:4]=[C:3]2[C:2](=[C:7]([C:8](=[O:17])[C:9]3[CH:10]=[CH:11][C:12]([S:15][CH3:16])=[CH:13][CH:14]=3)[CH:6]=1)[NH:22][C:20](=[O:21])[CH2:19]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 13394305HCID 13394305, compound

Product 1

HCID 13394292HCID 13394292, compoundYield 62%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 18.8 g (0.06 mole) of 2-amino-5-methyl-3-[4-(methylthio)benzoyl]phenylacetamide in 1700 ml of absolute ethanol with 16.6 ml (0.2 mol) of concentrated hydrochloric acid was heated at reflux for 45 min. The mixture was diluted with 50 ml of water and cooled. The precipitate was collected and recrystallized from 60% aqueous ethanol to give 11.0 g (62%) of the titled compound as tan crystals, m.p. 176.0°-177.5° C.

Workup

  1. temperatureat reflux for 45 min
  2. temperaturecooled
  3. customThe precipitate was collected
  4. customrecrystallized from 60% aqueous ethanol

Sources & evidence

ORD record
ord-e93d4c5f783f4af99f2c19ee54f2f184
Source dataset
uspto-grants-1985_03
Patent number
US04503073

Reaction notes

Loading…