Sodium Hydroxide → Calcium 2-[1-(ethoxyimino)propyl]-5-(4-methanesulfonamidophenyl)-3-oxo-1-cyclohexenolate
Reaction equation
[OH-].[Na+].[CH2:3]([O:5][N:6]=[C:7]([C:10]1[C:11](=[O:28])[CH2:12][CH:13]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=2)[CH2:14][C:15]=1[OH:16])[CH2:8][CH3:9])[CH3:4].[Cl-].[Ca+2:30].[Cl-]>>[CH2:3]([O:5][N:6]=[C:7]([C:10]1[C:11](=[O:28])[CH2:12][CH:13]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=2)[CH2:14][C:15]=1[O-:16])[CH2:8][CH3:9])[CH3:4].[Ca+2:30].[CH2:3]([O:5][N:6]=[C:7]([C:10]1[C:11](=[O:28])[CH2:12][CH:13]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=2)[CH2:14][C:15]=1[O-:16])[CH2:8][CH3:9])[CH3:4]Participants
4
Procedure
Into 20 ml of an aqueous solution containing 2% of sodium hydroxide was dissolved 1.9 g of 2-[1-(ethoxyimino)propyl]-5-(4-methanesulfonamidophenyl)-3-hydroxy-2-cyclohexen-1-one and to the solution was added 3 cc of an aqueous solution containing 10% of calcium chloride at room temperature. The water was removed under a reduced pressure and the residue was dissolved in ethanol and an insoluble sodium chloride was separated with a filtering step. The ethanol was distilled off under reduced pressure and 1.5 g of white powder having a melting point of 250° C. or more was obtained.
Workup
- customThe water was removed under a reduced pressure
- dissolutionthe residue was dissolved in ethanol
- customan insoluble sodium chloride was separated with a filtering step
- distillationThe ethanol was distilled off under reduced pressure and 1.5 g of white powder
- customwas obtained
Sources & evidence
- ORD record
- ord-1789c66d70ed4f79ae7f3768e5a9a3b3
- Source dataset
- uspto-grants-1985_03
- Patent number
- US04504305
Reaction notes
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