Hydrazine hydrate (1:1) → HCID 13116743, compound

HRID 2164397Notes

Reaction equation

HRID 2164397 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]2[S:15][C:14]([C:16](=O)[CH2:17][CH2:18][C:19]([OH:21])=O)=[CH:13][CH:12]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:24][NH2:25]>O>[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]2[S:15][C:14]([C:16]3[CH2:17][CH2:18][C:19](=[O:21])[NH:24][N:25]=3)=[CH:13][CH:12]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20405529HCID 20405529, compound

Product 1

HCID 13116743HCID 13116743, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

3.2 g of 4-{5-[5-(1-imidazolyl)-pentyl]-thien-2-yl}-4-oxo-butyric acid are suspended in 10 ml of water, 0.52 g of hydrazine hydrate are added and the mixture is stirred at 90° C. for 2 hours. After the mixture has been cooled, the precipitate formed is filtered off with suction, washed with water and dried.

Workup

  1. temperatureAfter the mixture has been cooled
  2. customthe precipitate formed
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-94a2f62f977e409e98731f56ddec9039
Source dataset
uspto-grants-1985_03
Patent number
US04504479

Reaction notes

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