反应详情

12 ml of methoxycarbonyl isothiocyanate are added dropwise, with stirring, to 18.7 g of 5-(3-trifluoromethylphenylsulfonyloxy)-2-ureidoaniline in 300 ml of dioxane, the temperature rising to about 40° C. The mixture is stirred for a further four hours without cooling, 60 ml of diisopropyl ether are added and the precipitate is filtered off with suction. After washing with diisopropyl ether, recrystallization is carried out from methanol/diisopropyl ether with the addition of active charcoal, melting point 190° C., decomposition.

1. customrising to about 40° C
2. temperaturewithout cooling
3. filtrationthe precipitate is filtered off with suction
4. washAfter washing with diisopropyl ether, recrystallization
5. additionis carried out from methanol/diisopropyl ether with the addition of active charcoal, melting point 190° C., decomposition.