反应详情

61.5 g of 5-(3-trifluoromethylphenylsulfonyloxy)-2-ureidonitrobenzene in 200 ml of methanol and 200 ml of 2-methoxyethanol are hydrogenated under normal pressure with a catalytic amount of Raney nickel. After hydrogen uptake is complete, the catalyst is filtered off with suction, washed with methanol and the solution is evaporated under reduced pressure, 1 liter of water is added, and the solid is filtered off with suction, washed with water and dried over NaOH, melting point 172° C., decomposition.

1. filtrationthe catalyst is filtered off with suction
2. washwashed with methanol
3. customthe solution is evaporated under reduced pressure, 1 liter of water
4. additionis added
5. filtrationthe solid is filtered off with suction
6. washwashed with water
7. dry with materialdried over NaOH, melting point 172° C., decomposition.