5-(3-Trifluoromethylphenylsulfonyloxy)-2-ureidonitrobenzene → 5-(3-Trifluoromethylphenylsulfonyloxy)-2-ureidoaniline

Participants

Reaction Steps

61.5 g of 5-(3-trifluoromethylphenylsulfonyloxy)-2-ureidonitrobenzene in 200 ml of methanol and 200 ml of 2-methoxyethanol are hydrogenated under normal pressure with a catalytic amount of Raney nickel. After hydrogen uptake is complete, the catalyst is filtered off with suction, washed with methanol and the solution is evaporated under reduced pressure, 1 liter of water is added, and the solid is filtered off with suction, washed with water and dried over NaOH, melting point 172° C., decomposition.

Provenance & Evidence