HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Amino-6-fluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2,6-Difluorobenzonitrile | HCID 74695 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-6-fluorobenzonitrile | HCID 522659 | — |
Reaction Steps
2,6-Difluorobenzonitrile, 19 g (0.14 mol) in 200 ml of ethanol saturated with NH3 at 0° C. is heated in a sealed vessel at 140° C. for 6 hrs. The mixture is evaporated to dryness, water is added and the product is collected and recrystallized from benzene, m.p. 128°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04504660 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-90d3d3dcedda40a48f00201c9bf9e774 |
| Source note | uspto-grants-1985_03 |