2-Amino-6-fluorobenzonitrile → 2-Amino-6-(methylamino)benzonitrile

HRID 2164445Notes

Reaction equation

HRID 2164445 reaction equation
C([O-])(=O)C.[CH3:5][NH3+:6].[NH2:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12](F)[C:9]=1[C:10]#[N:11]>CNC=O>[NH2:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([NH:6][CH3:5])[C:9]=1[C:10]#[N:11]

Participants

4

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 14420923Methylammoniumacetat

Product 1

HCID 127157172-Amino-6-(methylamino)benzonitrile

Reagents, catalysts & solvents 1

HCID 31254N-MethylformamideSolvent

Procedure

The title compound is prepared by heating a 10 molar excess of methylammonium acetate and 2-amino-6-fluorobenzonitrile in N-methyl formamide at 140° C. for 5 hrs.

Sources & evidence

ORD record
ord-2da8c8d506164326b39e6dbd2c51eba6
Source dataset
uspto-grants-1985_03
Patent number
US04504660

Reaction notes

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