6-Chloronicotinic acid → 2-Chloro-5-trichloromethylpyridine

HRID 2164455Notes

Reaction equation

HRID 2164455 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=O)=[CH:4][N:3]=1.ClC1N=CC(C(F)(F)F)=CC=1.[Cl-:22].[Al+3].[Cl-:24].[Cl-:25]>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([Cl:25])([Cl:24])[Cl:22])=[CH:9][CH:10]=1

Participants

4

Reactant 3

HCID 792226-Chloronicotinic acidHCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 6451240Aluminum(III) Chloride

Product 1

HCID 502932-Chloro-5-trichloromethylpyridine

Procedure

The process according to claim 4 wherein 6-chloronicotinic acid is produced by reacting 6-chloro-3-trifluoromethyl pyridine with aluminum chloride to obtain 6-chloro-3-trichloromethyl pyridine and then hydrolyzing the 6-chloro-3-trichloromethyl pyridine in the presence of sulfuric acid or phosphoric acid.

Workup

  1. customis produced

Sources & evidence

ORD record
ord-b382604850a54224bf35721363f957bd
Source dataset
uspto-grants-1985_03
Patent number
US04504665

Reaction notes

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