Water → HCID 13477003, compound

HRID 2164500Notes

Reaction equation

HRID 2164500 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[NH:4][N:3]=1.C(N(CC)CC)C.[Cl:18][CH:19]([Cl:23])[C:20](Cl)=[O:21].O>C(Cl)Cl>[C:7]([C:5]1[NH:4][N:3]=[C:2]([NH:1][C:20](=[O:21])[CH:19]([Cl:23])[Cl:18])[CH:6]=1)([CH3:10])([CH3:9])[CH3:8]

Participants

6

Reactant 4

HCID 962WaterHCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 5227873-Amino-5-tert-butylpyrazole

Product 1

HCID 13477003HCID 13477003, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.2 g (0.03 mole) of 3-amino-5-t-butylpyrazole prepared in Example 1 and 3.1 g of triethylamine were dissolved in 30 ml of methylene chloride, and 4.4 g of dichloroacetyl chloride was added dropwise thereto at about 30° C. The resulting mixture was allowed to stand over night. Thereafter, water was added thereto whereby crystals were precipitated. The crystals were collected by filtration and washed with water to obtain 5.0 g of 5-t-butyl-3-dichloroacetylaminopyrazole.

Workup

  1. customat about 30° C
  2. waitto stand over night
  3. customwhereby crystals were precipitated
  4. filtrationThe crystals were collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-2285b4faa74f423e8882c19cbfe466a4
Source dataset
uspto-grants-1985_03
Patent number
US04505739

Reaction notes

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