1-Methylpiperazine → HCID 86739980, compound

HRID 2164551Notes

Reaction equation

HRID 2164551 reaction equation
[CH3:1][CH:2]([NH:5][S:6]([C:9]1[CH:20]=[C:13]2[C:14]([O:16]C(=O)[NH:18][C:12]2=[CH:11][CH:10]=1)=O)(=[O:8])=[O:7])[CH2:3][CH3:4].[CH3:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>C(O)C.C(OCC)C>[CH3:21][N:22]1[CH2:27][CH2:26][N:25]([C:14](=[O:16])[C:13]2[C:12](=[CH:11][CH:10]=[C:9]([S:6](=[O:7])(=[O:8])[NH:5][CH:2]([CH2:3][CH3:4])[CH3:1])[CH:20]=2)[NH2:18])[CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 54130407HCID 54130407, compound

Product 1

HCID 86739980HCID 86739980, compound

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

In a manner analogous to that described in Example 1, the reaction of 5-[N-(2-butyl)-sulfamoyl]-isatoic anhydride with 1-methylpiperazine yields 5-[N-(2-butyl)-sulfamoyl]-anthranilic acid (4-methyl)-piperazide with a melting point of 130°-132° (from an ethanol/diethyl ether mixture). The hydrochloride melts at 246°-248°.

Sources & evidence

ORD record
ord-a21dd6d3b4f246e3b41809c9e3531527
Source dataset
uspto-grants-1985_03
Patent number
US04505913

Reaction notes

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