1-Methylpiperazine → HCID 86739981, compound

HRID 2164553Notes

Reaction equation

HRID 2164553 reaction equation
[CH:1]1([NH:7][S:8]([C:11]2[CH:22]=[C:15]3[C:16]([O:18]C(=O)[NH:20][C:14]3=[CH:13][CH:12]=2)=O)(=[O:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>C(O)C>[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:16](=[O:18])[C:15]2[C:14](=[CH:13][CH:12]=[C:11]([S:8](=[O:9])(=[O:10])[NH:7][CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH:22]=2)[NH2:20])[CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 53931880HCID 53931880, compound

Product 1

HCID 86739981HCID 86739981, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner analogous to that described in Example 1, the reaction of 5-(N-cyclohexylsulfamoyl)-isatoic anhydride with 1-methylpiperazine yields 5-(N-cyclohexylsulfamoyl)-anthranilic acid (4-methyl)-piperazide with a melting point of 167°-168° (from ethanol). The hydrochloride melts at 263°-264°.

Sources & evidence

ORD record
ord-12907c9cad004c4fbd9dbd143b089d2a
Source dataset
uspto-grants-1985_03
Patent number
US04505913

Reaction notes

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