1-Methylpiperazine → HCID 86739983, compound

HRID 2164557Notes

Reaction equation

HRID 2164557 reaction equation
[CH:1]([NH:4][S:5]([C:8]1[CH:19]=[C:12]2[C:13]([O:15]C(=O)[NH:17][C:11]2=[CH:10][CH:9]=1)=O)(=[O:7])=[O:6])([CH3:3])[CH3:2].[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(Cl)Cl.C(OCC)C>[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([C:13](=[O:15])[C:12]2[C:11](=[CH:10][CH:9]=[C:8]([S:5](=[O:6])(=[O:7])[NH:4][CH:1]([CH3:2])[CH3:3])[CH:19]=2)[NH2:17])[CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 54103255HCID 54103255, compound

Product 1

HCID 86739983HCID 86739983, compound

Reagents, catalysts & solvents 1

HCID 21881112Ethyl ether methylene chlorideSolvent

Procedure

In a manner analogous to that described in Example 1, the reaction of 5-(N-isopropylsulfamoyl)-isatoic anhydride with 1-methylpiperazine yields 5-(N-isopropylsulfamoyl)-anthranilic acid (4-methyl)-piperazide with a melting point of 118°-122° (from methylene chloride/diethyl ether; melting point of the methanesulfonate: 232°-234°).

Sources & evidence

ORD record
ord-46db058f14354b63a9685b0c6205187f
Source dataset
uspto-grants-1985_03
Patent number
US04505913

Reaction notes

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