Benzoic acid, 2-chloro-5-(chlorosulfonyl)- → 2-Chloro-5-(ethylsulfamoyl)benzoic acid

HRID 2164562Notes

Reaction equation

HRID 2164562 reaction equation
[CH2:1]([NH:3][S:4]([C:7]1[CH:18]=[C:11]2[C:12]([O:14]C(=O)[NH:16][C:10]2=[CH:9][CH:8]=1)=[O:13])(=[O:6])=[O:5])[CH3:2].[Cl:19]C1C=CC(S(Cl)(=O)=O)=CC=1C(O)=O>>[CH2:1]([NH:3][S:4]([C:7]1[CH:8]=[CH:9][C:10]([Cl:19])=[C:11]([CH:18]=1)[C:12]([OH:14])=[O:13])(=[O:6])=[O:5])[CH3:2].[CH2:1]([NH:3][S:4]([C:7]1[CH:18]=[C:11]([C:12]([OH:14])=[O:13])[C:10]([NH2:16])=[CH:9][CH:8]=1)(=[O:6])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 67306Benzoic acid, 2-chloro-5-(chlorosulfonyl)-HCID 53692218HCID 53692218, compound

Product 2

HCID 167683232-Chloro-5-(ethylsulfamoyl)benzoic acidHCID 20404880HCID 20404880, compound

Procedure

5-(N-Ethylsulfamoyl)-isatoic anhydride, which is to be used as the starting material, can be obtained, for example, in a manner analogous to that described in Example 1, using 2-chloro-5-chlorosulfonyl-benzoic acid as the starting material, the product being obtained via 5-(N-ethylsulfamoyl)-2-chloro-benzoic acid with a melting point of 186°-190° and 5-(N-ethylsulfamoyl)-anthranilic acid with a melting point of 190°-192°; the product melts at 253°-255°.

Sources & evidence

ORD record
ord-37bb5bb321584aa89ca3501b4501dcf8
Source dataset
uspto-grants-1985_03
Patent number
US04505913

Reaction notes

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