Triethylamine → HCID 12796233, compound

HRID 2164570Notes

Reaction equation

HRID 2164570 reaction equation
[N+](C1C=CC(O[C:11](=[O:24])[CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]=[CH2:22])=[C:15]([Cl:23])[CH:14]=2)=CC=1)([O-])=O.Cl.[CH3:26][O:27][C:28](=[O:31])[CH2:29][NH2:30].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:26][O:27][C:28](=[O:31])[CH2:29][NH:30][C:11](=[O:24])[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]=[CH2:22])=[C:15]([Cl:23])[CH:14]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 122755Glycine methyl ester hydrochlorideHCID 13384709HCID 13384709, compound

Product 1

HCID 12796233HCID 12796233, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Conditions

Temperature
40 °C

Procedure

4-Allyloxy-3-chloro-phenylacetic acid p-nitrophenyl ester (3.69 g) was dissolved in chloroform (30 ml). To the solution was added glycine methyl ester hydrochloride (1.5 g) in dry chloroform (30 ml) containing dry triethylamine (1.4 ml), and the solution was stirred at 40° C. for 4 hrs.

Sources & evidence

ORD record
ord-9603423fb5324a3dadd784efa668de00
Source dataset
uspto-grants-1985_03
Patent number
US04505898

Reaction notes

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