反应详情

To a solution of 5.29 g (0.0200 mole) of 4-(4-(methylsulfonyl)phenoxy)phenol and 1.51 g (0.0200 mole) of 2-chloroacetonitrile in 100 ml of acetonitrile was added 3.0 g (0.0220 mole) of K2CO3. The mixture was heated at reflux for 3.5 hrs and cooled. The mixture was poured into aqueous NaOH and the product extracted from the mixture with CH2Cl2. The organic layer was extracted with aqueous NaOH, water and dried (Na2SO4). Removal of solvent in vacuo afforded 5.6 g (92.4% yield) of product. Recrystallization from ethanol followed by washing with aqueous NaOH and water afforded purified (4-(4-(methylsulfonyl)phenoxy)phenoxy)acetonitrile, mp 114°-115.5° C.

1. temperatureThe mixture was heated
2. temperatureat reflux for 3.5 hrs
3. temperaturecooled
4. extractionthe product extracted from the mixture with CH2Cl2
5. extractionThe organic layer was extracted with aqueous NaOH, water
6. dry with materialdried (Na2SO4)
7. customRemoval of solvent in vacuo