Piperidine → HCID 12798203, compound

HRID 2164668Notes

Reaction equation

HRID 2164668 reaction equation
Br[CH2:2][CH:3]1[CH2:7][O:6][C:5]2([CH:15]([Br:16])[CH2:14][CH2:13][C:12]3[N:11]([S:17]([C:20]4[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=4)(=[O:19])=[O:18])[CH:10]=[CH:9][C:8]2=3)[O:4]1.[NH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[N:27]1([CH2:2][CH:3]2[CH2:7][O:6][C:5]3([CH:15]([Br:16])[CH2:14][CH2:13][C:12]4[N:11]([S:17]([C:20]5[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=5)(=[O:18])=[O:19])[CH:10]=[CH:9][C:8]3=4)[O:4]2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 12946388HCID 12946388, compound

Product 1

HCID 12798203HCID 12798203, compoundYield 75%

Procedure

Heating of 4'-bromomethyl-5-bromo-1-p-toluenesulfonyl-4,5,6,7-tetrahydroindole-4-spiro-2'-[1,3]dioxolane with piperidine at 80° C. for 3 hours affords 4'-piperidinomethyl-5-bromo-1-p-toluenesulfonyl-4,5,6,7-tetrahydroindole-4-spiro-2'-[1,3]dioxolane in 75% yield.

Sources & evidence

ORD record
ord-5d47a0fdd30341008dad0b539640a2e2
Source dataset
uspto-grants-1985_03
Patent number
US04506079

Reaction notes

Loading…