Thiophenol → HCID 13088594, compound

HRID 2164702Notes

Reaction equation

HRID 2164702 reaction equation
[CH3:1][C:2]([CH3:20])([CH3:19])[C:3](=[O:18])[C:4]([N:13]1[CH:17]=[N:16][CH:15]=[N:14]1)=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.[C:21]1([SH:27])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(O)C>[CH3:1][C:2]([CH3:20])([CH3:19])[C:3](=[O:18])[CH:4]([N:13]1[CH:17]=[N:16][CH:15]=[N:14]1)[CH:5]([C:6]1[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=1)[S:27][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 7969ThiophenolHCID 54425252HCID 54425252, compound

Product 1

HCID 13088594HCID 13088594, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

27.3 g (0.1 mol) of 4,4-dimethyl-1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)-pent-1-en-3-one (E,Z isomer mixture) and 11 g (0.1 mol) of thiophenol were stirred with 100 ml of ethanol at room temperature. After 1 hour, the crystals which had separated out were filtered off and dried. 34.7 g (91% of theory) of 4,4-dimethyl-1-(4-fluorophenyl)-1-phenylthio-2-(1,2,4-triazol-1-yl)-pentan-3-one, of melting point 175° C., were obtained.

Workup

  1. customthe crystals which had separated out
  2. filtrationwere filtered off
  3. customdried

Sources & evidence

ORD record
ord-64a9f2656bec48e0a52991267d4c1dd0
Source dataset
uspto-grants-1985_03
Patent number
US04507141

Reaction notes

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