Hydrazine hydrate (1:1) → HCID 13116735, compound

HRID 2164732Notes

Reaction equation

HRID 2164732 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH2:16][CH2:17][C:18]([OH:20])=O)=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:23][NH2:24]>O>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH2:16][CH2:17][C:18](=[O:20])[NH:23][N:24]=3)=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13132611HCID 13132611, compound

Product 1

HCID 13116735HCID 13116735, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

2 g of 4-{4-[3-(1-imidazolyl)-propyl]-phenyl}-4-oxo-butyric acid are suspended in 10 ml of water, 0.68 g of hydrazine hydrate are added and the mixture is then stirred at 90° C. for 2 hours. After the mixture has been cooled, it is extracted with chloroform and the chloroform solution is washed with water, dried over Na2SO4 and concentrated to dryness.

Workup

  1. temperatureAfter the mixture has been cooled
  2. extractionit is extracted with chloroform
  3. washthe chloroform solution is washed with water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-6e4df376bcff41eb965e4c50415d4719
Source dataset
uspto-grants-1985_03
Patent number
US04507298

Reaction notes

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