反应详情

温度

120 °C

A mixture comprising 10.62 g of N-(8-trifluoromethyl-4-quinolyl)-anthranilic acid sodium salt, 4.98 g of 90% 3-(β-chloroethyl)-oxazolidin-2-one and 60 ml of dimethylformamide was heated under stirring at 120° C. for five hours. Upon completion of the reaction, the mixture was cooled, filtered, and poured into 300 ml of water. The crude product was extracted with ethyl acetate, the solvent evaporated off and the residue crystallized from ethanol to give 6 g of N-(8-trifluoromethyl-4-quinolyl)-anthranilic acid β-(2-oxo-3-oxazolidinyl)-ethyl ester, melting at 158°-160° C.

1. temperaturewas heated
2. customUpon completion of the reaction
3. temperaturethe mixture was cooled
4. filtrationfiltered
5. additionpoured into 300 ml of water
6. extractionThe crude product was extracted with ethyl acetate
7. customthe solvent evaporated off
8. customthe residue crystallized from ethanol