8-Chloro-6-(2-chlorophenyl)-4H-imidazo(1,5-a)(1,4)-benzodiazepine-3-carboxamide → HCID 20403325, compound

HRID 2164777Notes

Reaction equation

HRID 2164777 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]([NH2:17])=[O:16])=[C:10]3[CH2:9][N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:6]=2[CH:25]=1.CC(C)C(O)=O.[CH3:32][C:33]([N:35]([CH3:37])[CH3:36])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]([N:17]=[CH:32][CH2:33][N:35]([CH3:37])[CH3:36])=[O:16])=[C:10]3[CH2:9][N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:6]=2[CH:25]=1

Participants

3

Reactant 2

HCID 1629978-Chloro-6-(2-chlorophenyl)-4H-imidazo(1,5-a)(1,4)-benzodiazepine-3-carboxamideHCID 88126211HCID 88126211, compound

Product 1

HCID 20403325HCID 20403325, compound

Conditions

Temperature
115 °C

Procedure

A mixture of 0.0047 mole 8-chloro-6-(2-chlorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide and 3 ml of dimethyl acetamide dimethyl acetate was heated in an oil bath at a temperature of about 115° C. After cooling the crystals were collected on a glass filter and washed with dimethyl formamide (DMF) and ether.

Workup

  1. temperatureAfter cooling the crystals
  2. customwere collected on a glass
  3. filtrationfilter
  4. washwashed with dimethyl formamide (DMF) and ether

Sources & evidence

ORD record
ord-72c1db8645d746fba908c98bdfd3b92a
Source dataset
uspto-grants-1985_03
Patent number
US04507313

Reaction notes

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