Isatoic Anhydride → 2-amino-N-(3-imidazol-1-ylpropyl)benzamide

HRID 2164786Notes

Reaction equation

HRID 2164786 reaction equation
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[N:13]1([CH2:18][CH2:19][CH2:20][NH2:21])[CH:17]=[CH:16][N:15]=[CH:14]1>O1CCOCC1>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:21][CH2:20][CH2:19][CH2:18][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:4]

Participants

4

Reactant 2

HCID 8359Isatoic AnhydrideHCID 787361H-Imidazole-1-propanamine

Product 1

HCID 27983352-amino-N-(3-imidazol-1-ylpropyl)benzamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Isatoic anhydride (22.0 g) was added in portions to a stirred solution of 3-imidazol-1-ylpropylamine (17.2 g) in dioxan (100 ml) over a period of 15 minutes. Stirring was continued for 40 minutes before the solution was evaporated in vacuo to give 2-amino-N-(3-imidazol-1-ylpropyl)benzamide as a buff coloured solid, used without further purification.

Workup

  1. customwas evaporated in vacuo

Sources & evidence

ORD record
ord-dac112eea72f4d938ba811a09fbdef49
Source dataset
uspto-grants-1985_03
Patent number
US04507315

Reaction notes

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