1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 20237885, compound

HRID 2164904Notes

Reaction equation

HRID 2164904 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][NH:8][C:9]2[C:10]([CH3:16])=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])C(=O)C2=CC=CC=C12.NC1C(C)=NN(C)C=1C.BrCCN1C(=O)C2=CC=CC=C2C1=O.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[NH2:5][CH2:6][CH2:7][NH:8][C:9]1[C:10]([CH3:16])=[N:11][N:12]([CH3:15])[C:13]=1[CH3:14]

Participants

6

Reactant 4

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 11430Potassium CarbonateHCID 1616031,3,5-trimethyl-1H-pyrazol-4-amineHCID 12818864HCID 12818864, compound

Product 1

HCID 20237885HCID 20237885, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The 4-(2-phthalimidoethylamino)-1,3,5-trimethylpyrazole used as starting material is obtained in good yield by reacting 4-amino-1,3,5-trimethylpyrazole with N-(2-bromoethyl)-phthalimide in acetonitrile in the presence of potassium carbonate for 16 hours under reflux. It is obtained in the form of yellowish crystals which melt at 122°-123° C., after recrystallization from ethanol.

Workup

  1. customis obtained
  2. customin good yield
  3. customfor 16 hours
  4. temperatureunder reflux
  5. customIt is obtained in the form of yellowish crystals which
  6. custommelt at 122°-123° C.
  7. customafter recrystallization from ethanol

Sources & evidence

ORD record
ord-790a835c5f6c4d329f4e522ab9d68d4b
Source dataset
uspto-grants-1985_03
Patent number
US04507488

Reaction notes

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