Benzylamine → HCID 54256026, compound

HRID 2164907Notes

Reaction equation

HRID 2164907 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[N:10]([CH3:11])[N:9]=[CH:8][C:7]=1[CH3:12])=[O:4].[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CN(C)C=O.O>[CH2:13]([NH:20][CH2:2][C:3]([NH:5][C:6]1[N:10]([CH3:11])[N:9]=[CH:8][C:7]=1[CH3:12])=[O:4])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 2

HCID 7504BenzylamineHCID 20403520HCID 20403520, compound

Product 1

HCID 54256026HCID 54256026, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

35 g of 5-(chloroacetamido)-1,4-dimethyl-pyrazole are dissolved in 300 ml of absolute dimethyl formamide and the solution, subsequent to the addition of 46 g of benzylamine, heated to 100° C. for 3 h. The cooled solution is diluted with water and extracted with dichloromethane. The dichloromethane phase is washed with a saturated table-salt solution, dried on sodium sulfate, and concentrated by evaporation. The residue is recrystallized from ethyl acetate.

Workup

  1. extractionextracted with dichloromethane
  2. washThe dichloromethane phase is washed with a saturated table-salt solution
  3. customdried on sodium sulfate
  4. concentrationconcentrated by evaporation
  5. customThe residue is recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-e7f5d350e4b24b39bbff29c5fb9f68d3
Source dataset
uspto-grants-1985_03
Patent number
US04507488

Reaction notes

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