HRID2164976

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID6328

Methyl iodide

CH3I

HCID11430

Potassium Carbonate

CK2O3

$结构：CCOC(=O)/C(=N\O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1$

HCID6410761

未命名化合物

PRODUCTS

生成物

$结构：CCOC(=O)/C(=N\OC)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1$

HCID6005279

4-Thiazoleacetic acid, α-(methoxyimino)-2-[(triphenylmethyl)amino]-, ethyl ester, (Z)-

C27H25N3O3S

收率 100.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

A mixture of ethyl (Z)-2-hydroxyimino-2-(2-tritylaminothiazol-4-yl)acetate (II) (5.00 g, 10.9 mmoles), CH3I (2.04 mL, 32.8 mmoles) and K2CO3 (4.54 g, 32.8 mmoles) in dry dimethylsulfoxide (DMSO) (100 mL) was stirred at room temperature overnight and then poured into water (250 mL). The precipitate which formed was collected by filtration, washed with water and dried to give the title compound (5.15 g, quantitative yield). Mp. 115° C. (dec.).

WORKUP

后处理

customThe precipitate which formed
filtrationwas collected by filtration
washwashed with water
customdried