(5-Methylpyrimidin-2-yl)methanol → 5-Methylpyrimidine-2-carbaldehyde

HRID 2164994Notes

Reaction equation

HRID 2164994 reaction equation
[OH:1][CH2:2][C:3]1[N:8]=[CH:7][C:6]([CH3:9])=[CH:5][N:4]=1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[CH3:9][C:6]1[CH:5]=[N:4][C:3]([CH:2]=[O:1])=[N:8][CH:7]=1

Participants

4

Reactant 1

HCID 23043337(5-Methylpyrimidin-2-yl)methanol

Product 1

HCID 230433365-Methylpyrimidine-2-carbaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

5-Methylpyrimidine-2-carboxaldehyde was prepared from 2-hydroxymethyl-5-methylpyrimidine by oxidation with excess manganese dioxide in boiling chloroform. The product was obtained as colourless crystals and was characterized by proton nuclear magnetic resonance spectroscopy. Proton nuclear magnetic resonance spectrum (CDCl3 ; δ in ppm): 2.44 (3H,s); 8.80 (2H,s); 10.06 (1H,s).

Workup

  1. customThe product was obtained as colourless crystals

Sources & evidence

ORD record
ord-2bdf565a13fb4b56a4133264da693543
Source dataset
uspto-grants-1990_07
Patent number
US04938793

Reaction notes

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