Sodium Hydroxide → HCID 23675394, compound

HRID 2164998Notes

Reaction equation

HRID 2164998 reaction equation
[F:1][C:2]([F:29])([F:28])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:19]3[C:14](=[C:15]([O:20][CH:21]([F:23])[F:22])[CH:16]=[CH:17][CH:18]=3)[C:13](=[O:24])[C:12]([C:25]([OH:27])=[O:26])=[N:11]2)=[CH:6][CH:5]=1.[OH-].[Na+:31]>O>[F:29][C:2]([F:1])([F:28])[O:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:19]3[C:14](=[C:15]([O:20][CH:21]([F:23])[F:22])[CH:16]=[CH:17][CH:18]=3)[C:13](=[O:24])[C:12]([C:25]([O-:27])=[O:26])=[N:11]2)=[CH:8][CH:9]=1.[Na+:31]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15630311HCID 15630311, compound

Product 1

HCID 23675394HCID 23675394, compoundYield 78.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-(4-Trifluoromethoxyphenyl)-1,4-dihydro-4-oxo-5-difluoromethoxycinnoline-3-carboxylic acid (120 mg) and a 1N aqueous solution of sodium hydroxide (0.265 ml) were added to water (5 ml), and the mixture was stirred at room temperature for 1 hour. The resultant mixture was washed with ethyl acetate (10 ml). After removing the water, the obtained crystals were dried to give 91 mg of desired sodium 1-(4-trifluoromethoxyphenyl)-1,4-dihydro-4-oxo-5-difluoromethoxycinnoline-3-carboxylate (yield: 78.4%). m.p., 165°-169° C.

Workup

  1. washThe resultant mixture was washed with ethyl acetate (10 ml)
  2. customAfter removing the water
  3. customthe obtained crystals were dried

Sources & evidence

ORD record
ord-e172240def1c42758ada57ffb6b75fd4
Source dataset
uspto-grants-1990_07
Patent number
US04938794

Reaction notes

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