Sodium Hydroxide → HCID 23675394, compound

Participants

Reaction Steps

1-(4-Trifluoromethoxyphenyl)-1,4-dihydro-4-oxo-5-difluoromethoxycinnoline-3-carboxylic acid (120 mg) and a 1N aqueous solution of sodium hydroxide (0.265 ml) were added to water (5 ml), and the mixture was stirred at room temperature for 1 hour. The resultant mixture was washed with ethyl acetate (10 ml). After removing the water, the obtained crystals were dried to give 91 mg of desired sodium 1-(4-trifluoromethoxyphenyl)-1,4-dihydro-4-oxo-5-difluoromethoxycinnoline-3-carboxylate (yield: 78.4%). m.p., 165°-169° C.

Provenance & Evidence