Ammonium Chloride → HCID 23043558, compound

HRID 2165045Notes

Reaction equation

HRID 2165045 reaction equation
C([C:8]1[N:9]=[C:10]([CH2:13][CH:14]([P:23]([O:28][CH2:29][CH3:30])(=[O:27])[O:24][CH2:25][CH3:26])[P:15]([O:20][CH2:21][CH3:22])(=[O:19])[O:16][CH2:17][CH3:18])[NH:11][CH:12]=1)C1C=CC=CC=1.[Na].[Cl-].[NH4+]>N>[NH:9]1[CH:8]=[CH:12][N:11]=[C:10]1[CH2:13][CH:14]([P:23]([O:28][CH2:29][CH3:30])(=[O:27])[O:24][CH2:25][CH3:26])[P:15]([O:20][CH2:21][CH3:22])(=[O:19])[O:16][CH2:17][CH3:18]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 178476972HCID 178476972, compound

Product 1

HCID 23043558HCID 23043558, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

3.3 g (0.0072 mole) of tetraethyl 2-(benzylimidazol-2-yl)ethane-1,1-diphosphonate are dissolved in 50 ml of liquid ammonia and, with stirring, 1.0 g of sodium is added gradually in small portions until the blue colour of the solution is maintained for some time. Then 2.35 g of ammonium chloride are added in portions. The ammonia is then removed by evaporation, the residue is taken up in diethyl ether, the solution is filtered and the filtrate is concentrated by evaporation, affording tetraethyl 2-(imidazol-2-yl)ethane-1,1-diphosphonate as a colourless oil.

Workup

  1. temperatureis maintained for some time
  2. customThe ammonia is then removed by evaporation
  3. filtrationthe solution is filtered
  4. concentrationthe filtrate is concentrated by evaporation

Sources & evidence

ORD record
ord-c53e60fa0f2f4613b270877eaace88e0
Source dataset
uspto-grants-1990_07
Patent number
US04939130

Reaction notes

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