Tetraethyl methylenediphosphonate → HCID 23043560, compound

HRID 2165047Notes

Reaction equation

HRID 2165047 reaction equation
C1(C)C=CC(S(O[CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)(=O)=O)=CC=1.[CH2:18]([P:27]([O:32]CC)(=[O:31])[O:28]CC)[P:19]([O:24]CC)(=[O:23])[O:20]CC.C(P([O-])(=O)[O-])CP([O-])(=O)[O-]>>[N:12]1([CH2:11][CH:18]([P:27]([OH:32])(=[O:28])[OH:31])[P:19]([OH:24])(=[O:20])[OH:23])[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

4

Reactant 3

HCID 15455Tetraethyl methylenediphosphonateHCID 7067518HCID 7067518, compoundHCID 17803456HCID 17803456, compound

Product 1

HCID 23043560HCID 23043560, compound

Procedure

Reaction of (imidazol-1-ylmethyl) p-toluenesulfonate with tetraethyl methanediphosphonate and hydrolysis of the primary ethanediphosphonate in accordance with Example 2 gives 2-(imidazol-1-yl)ethane-1,1-diphosphonic acid of m.p. 255° C. (dec.) and salts thereof, e.g. the disodium salt.

Sources & evidence

ORD record
ord-4f12af23538847e5b10caaa4a4be2d4e
Source dataset
uspto-grants-1990_07
Patent number
US04939130

Reaction notes

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