HCID 14810761, compound → HCID 14810645, compound

HRID 2165075Notes

Reaction equation

HRID 2165075 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([O:28]C)[C:6]2[S:10][C:9]([CH2:11][N:12]3[C:21](=[O:22])[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:14]([CH2:23][C:24]([OH:26])=[O:25])=[N:13]3)=[N:8][C:7]=2[CH:27]=1>Br>[OH:2][C:3]1[CH:4]=[C:5]([OH:28])[C:6]2[S:10][C:9]([CH2:11][N:12]3[C:21](=[O:22])[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:14]([CH2:23][C:24]([OH:26])=[O:25])=[N:13]3)=[N:8][C:7]=2[CH:27]=1

Participants

3

Reactant 1

HCID 14810761HCID 14810761, compound

Product 1

HCID 14810645HCID 14810645, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A mixture of 3-(5,7-dimethoxy-2-benzothiazolylmethyl)-4-oxo-3H-phthalazin-1-yl acetic acid (0.5 g) and aqueous hydrobromic acid (10 ml, 48%) was refluxed for 4 hours. The hot solution was cooled to room temperature and than poured onto ice-water (50 ml). The resulting pink colored solid was filtered, washed with water (20 ml) and dried. The dried solid was crystallized from methanol to yield the product (0.31 g; m.p. 184° C.).

Workup

  1. temperaturewas refluxed for 4 hours
  2. additionthan poured onto ice-water (50 ml)
  3. filtrationThe resulting pink colored solid was filtered
  4. washwashed with water (20 ml)
  5. customdried
  6. customThe dried solid was crystallized from methanol
  7. customto yield the product (0.31 g; m.p. 184° C.)

Sources & evidence

ORD record
ord-209ec8830aaa455286ef44bd2c69d675
Source dataset
uspto-grants-1990_07
Patent number
US04939140

Reaction notes

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