Formic Acid → HCID 23043601, compound

HRID 2165092Notes

Reaction equation

HRID 2165092 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][CH:26]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:32](O)=[O:33]>C1(C)C=CC=CC=1>[CH:32]([NH:31][C:28]1[CH:27]=[CH:26][C:25]([CH2:24][CH2:23][C:11]2[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:10]=2)=[CH:30][CH:29]=1)=[O:33]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 23043605HCID 23043605, compound

Product 1

HCID 23043601HCID 23043601, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The 4-[2-(3,4-dibenzyloxyphenyl)ethyl]benzenamine (4.5 g, 11 mmole) is dissolved in toluene (75 ml) containing formic acid (0.51 g, 11 mmole) and refluxed for two hours. The reaction mixture is evaporated to dryness, and the residue is recrystallized from toluene to afford 4.7 g (97%) of N-formyl-4-[2-(3,4-dibenyloxyphenyl)ethyl]benzeneamine, mp 119°-122° C.

Workup

  1. temperaturerefluxed for two hours
  2. customThe reaction mixture is evaporated to dryness
  3. customthe residue is recrystallized from toluene

Sources & evidence

ORD record
ord-c8d60c26b0a14effa4df9932178e7803
Source dataset
uspto-grants-1990_07
Patent number
US04939133

Reaction notes

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