4-(3,4-Dimethoxyphenethyl)aniline → HCID 23043617, compound

HRID 2165099Notes

Reaction equation

HRID 2165099 reaction equation
C[Si]1(C)O[C:6](=[O:8])[C:5]2[CH:9]=[CH:10][C:11]([CH3:13])=[CH:12][C:4]=2[O:3]1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=2)[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH2:25][CH2:26][C:27]2[CH:28]=[CH:29][C:30]([NH:33][C:6](=[O:8])[C:5]3[CH:9]=[CH:10][C:11]([CH3:13])=[CH:12][C:4]=3[OH:3])=[CH:31][CH:32]=2)[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 142560244-(3,4-Dimethoxyphenethyl)anilineHCID 23043608HCID 23043608, compound

Product 1

HCID 23043617HCID 23043617, compoundYield 48.5%

Procedure

The preparation is as described for Example 45 using 2,2,7trimethyl-4H-1,3,2-benzodioxasilin-4-one (2.0 g, 10 mmol) and 4[2-(3,4-dimethoxyphenyl)ethyl]benzenamine (2.5 g, 10 mmol). Recrystallization from methanol/DMF gives the pure product (1.9 g) mp 162°-164° C.

Workup

  1. customRecrystallization from methanol/DMF

Sources & evidence

ORD record
ord-3242f786f1614811907d73dded510375
Source dataset
uspto-grants-1990_07
Patent number
US04939133

Reaction notes

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