反应详情

A mixture of 2,3-benzofurandione (Fries and Pfaffendorf, Ber, 45, 156 (1912); Valentine, Titoff, Muller, and Reichstein, Helv. Chim. Acta, 20, 883 (1937)) (10 g, 0.0675 mol) and 4-[2-(4-aminophenyl)ethyl]-1,2-dimethoxybenzene (15.6 g, 0.0606 mol) in dry tetrahydrofuran is stirred at room temperature under nitrogen for 18 hours in the dark. The solvent is removed under reduced pressure on a rotary evaporator below 35° and the resulting solid is recrystallized from tetrahydrofuran-ethanol to give 22.2 g (90.6%) of a light-yellow solid, mp 124°-125° C.

1. customThe solvent is removed under reduced pressure on a rotary evaporator below 35°
2. customthe resulting solid is recrystallized from tetrahydrofuran-ethanol