Methylparaben → 4-Cyclohexylmethoxycinnamic acid methyl ester

HRID 2165179Notes

Reaction equation

HRID 2165179 reaction equation
[CH3:1][O:2][C:3](=[O:13])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Cl[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.COC(=O)C1C=CC(O)=CC=1.CC1(C)CCCC(C)C1CCC(Cl)C>>[CH3:1][O:2][C:3](=[O:13])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:8][CH:7]=1

Participants

5

Reactant 4

HCID 7456MethylparabenHCID 92203Methyl p-coumarateHCID 3015335(Chloromethyl)cyclohexaneHCID 144574904-(1,1,3-Trimethyl-2-cyclohexyl)-2-butyl chloride

Product 1

HCID 537861274-Cyclohexylmethoxycinnamic acid methyl ester

Procedure

(melting point: 104° C.) was prepared by the method described in 1.1 by substituting, on an equimolar basis, 4-hydroxy-cinnamic acid methyl ester and chloromethyl cyclohexane for the 4-hydroxybenzoic acid methyl ester and 4-(1,1,3-trimethyl-2-cyclohexyl)-2-butyl chloride used in Example 1.1.

Workup

  1. custom(melting point: 104° C.) was prepared by the method

Sources & evidence

ORD record
ord-f9541eacbb4348afbe800a311fa17c53
Source dataset
uspto-grants-1990_07
Patent number
US04939171

Reaction notes

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