反应详情

The above urea (12.41 g, 37.5 mmol) was reacted with 1-(3-trifluoromethylphenyl)piperazine hydrochloride (15 g, 56.2 mmol) as described in Example 12 to produce 5.8 g (34%) of the known 3-[4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl]thieno[3,4-d]pyrimidine-2,4-dione (J. Press and R. Russell, U.S. Pat. No. 4,670,560) after recrystallization from CH2Cl2 /hexane as a white solid, mp 126°-128° C.