HuagongsheHuagongshe Chemistry Print Report · For research reference only
TFMPP hydrochloride → 3-[4-[4-(3-Trifluoromethylphenyl)piperazin-1-yl]butyl]thieno[3,4-d]pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | TFMPP hydrochloride | HCID 3084246 | — |
| Reactant | N-(4-bromobutyl)-N'-(4-carbomethoxythien-3-yl)urea | HCID 15697666 | — |
| Product | 3-[4-[4-(3-Trifluoromethylphenyl)piperazin-1-yl]butyl]thieno[3,4-d]pyrimidine-2,4-dione | HCID 15070692 | 34.2% |
Reaction Steps
The above urea (12.41 g, 37.5 mmol) was reacted with 1-(3-trifluoromethylphenyl)piperazine hydrochloride (15 g, 56.2 mmol) as described in Example 12 to produce 5.8 g (34%) of the known 3-[4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl]thieno[3,4-d]pyrimidine-2,4-dione (J. Press and R. Russell, U.S. Pat. No. 4,670,560) after recrystallization from CH2Cl2 /hexane as a white solid, mp 126°-128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04939137 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-3850487022124ad09b6bb9fd8c1344c9 |
| Source note | uspto-grants-1990_07 |