HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-[3-[4-[4-(4-fluorobenzoyl)piperidin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate → 3-[3-[4-[4-(4-Fluorobenzoyl)piperidin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-[3-[4-[4-(4-fluorobenzoyl)piperidin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate | HCID 15070686 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-[3-[4-[4-(4-Fluorobenzoyl)piperidin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid | HCID 23043680 | 86.8% |
Reaction Steps
The above ester (1.6 g, 3.1 mmol) was hydrolyzed to its corresponding carboxylic acid as described in Example 1. There was obtained 1.35 g (86.7%) of 3-[3-[4-[4-(4-fluorobenzoyl)piperidin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoic acid after trituration with ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04939137 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-e36e34e24b1c4ce0a3e9e9741dc33cbd |
| Source note | uspto-grants-1990_07 |