Hydrochloric Acid → HCID 14452901, compound

HRID 2165260Notes

Reaction equation

HRID 2165260 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([Cl:11])[CH:5]=[C:4]([CH2:12][CH3:13])[N:3]=1.Cl[Sn]Cl.Cl.[OH-].[Na+]>>[NH2:8][C:7]1[C:2]([Cl:1])=[N:3][C:4]([CH2:12][CH3:13])=[CH:5][C:6]=1[Cl:11]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24479Stannous ChlorideHCID 14452905HCID 14452905, compound

Product 1

HCID 14452901HCID 14452901, compound

Procedure

9 g (40.7 mmol) of 2,4-dichloro-6-ethyl-3-nitropyridine are introduced into a solution of 33 g (0.146 mol) of SnCl2. 2H2O in 100 ml of 36% strength HCl and the mixture is boiled under reflux for 30 minutes. It is then cooled and stirred into 400 ml of 12% strength NaOH with cooling. It is extracted three times using 150 ml of dichloromethane each time and the extract is dried using Na2SO4 and evaporated.

Workup

  1. temperatureunder reflux for 30 minutes
  2. temperatureIt is then cooled
  3. temperaturewith cooling
  4. extractionIt is extracted three times
  5. customthe extract is dried
  6. customevaporated

Sources & evidence

ORD record
ord-63f2e89df7d746b9bab1be7990dff5b7
Source dataset
uspto-grants-1990_07
Patent number
US04939262

Reaction notes

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