Chloroform → HCID 14452909, compound

HRID 2165264Notes

Reaction equation

HRID 2165264 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([Cl:10])[C:7]([NH2:11])=[C:6]([Cl:12])[CH:5]=1)(=[O:3])[CH3:2].C([O-])(O)=O.[Na+].C(Cl)(Cl)[Cl:19]>>[NH2:11][C:7]1[C:8]([Cl:10])=[N:9][C:4]([C:1](=[O:3])[CH2:2][Cl:19])=[CH:5][C:6]=1[Cl:12]

Participants

4

Reactant 3

HCID 6212Chloroform2×HCID 516892Sodium BicarbonateHCID 14452904HCID 14452904, compound

Product 1

HCID 14452909HCID 14452909, compound

Conditions

Temperature
40 °C

Procedure

14 g (68.3 mmol) of 6-acetyl-3-amino-2,4-dichloropyridine are dissolved in 70 ml of dry CHCl3 and then a solution of 5.5 ml (68.4 mmol) of SO2Cl2 in 70 ml of dry CHCl3 is added dropwise and the mixture is stirred for two hours at 40° C. For working up, it is poured into 250 ml of NaHCO3 solution, and the organic phase is separated off and extracted once more using 100 ml of CHCl3. The combined organic phases are dried using Na2SO4 and evaporated.

Workup

  1. customthe organic phase is separated off
  2. extractionextracted once more
  3. customThe combined organic phases are dried
  4. customevaporated

Sources & evidence

ORD record
ord-c12badbd040641bfbd9f2a5afd185321
Source dataset
uspto-grants-1990_07
Patent number
US04939262

Reaction notes

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