Trimethyl phosphite → HCID 14423944, compound

HRID 2165324Notes

Reaction equation

HRID 2165324 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)=[C:9]([C:12]2[N:16]([CH3:17])[N:15]=[N:14][N:13]=2)[CH2:10]Br)=[CH:4][CH:3]=1.[P:25]([O:30]C)([O:28][CH3:29])[O:26][CH3:27]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)=[C:9]([C:12]2[N:16]([CH3:17])[N:15]=[N:14][N:13]=2)[CH2:10][P:25](=[O:30])([O:28][CH3:29])[O:26][CH3:27])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8472Trimethyl phosphiteHCID 14423941HCID 14423941, compound

Product 1

HCID 14423944HCID 14423944, compound

Procedure

A slurry of 3,3-bis-(4-fluorophenyl)-1-bromo-2-(1-methyl-1H-tetrazol-5-yl)-2-propene (1.17 g, 3.0 mmol) and trimethyl phosphite (0.41 g, 3.3 mmol) was heated at 100° C. for 5 minutes. After cooling to ambient temperature, excess trimethylphosphite was removed in vacuo to give a light yellow solid. This solid was recrystallized from ethylacetate/hexane mixture to give the title compound as a pure white solid; m.p.=140°-141° C.

Workup

  1. customexcess trimethylphosphite was removed in vacuo
  2. customto give a light yellow solid
  3. customThis solid was recrystallized from ethylacetate/hexane mixture

Sources & evidence

ORD record
ord-889e769df0cc4aa2b642d11df1d9ec58
Source dataset
uspto-grants-1990_07
Patent number
US04939265

Reaction notes

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