Acetic Acid → HCID 178476703, compound

HRID 2165547Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH2:12])=[CH:9][CH:8]=[CH:7][CH:6]=2.[Cl:13][C:14]([Cl:20])([Cl:19])[C:15](=[NH:18])OC.[C:21]([OH:24])(=[O:23])[CH3:22]>>[C:21]([OH:24])(=[O:23])[CH3:22].[NH2:12][C:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[NH:1][C:15](=[NH:18])[C:14]([Cl:20])([Cl:19])[Cl:13]

Participants

Reactant 3

HCID 176Acetic Acid

HCID 100479Methyl 2,2,2-trichloroacetimidate

HCID 15142893,4-Diaminoquinoline

Product 1

HCID 178476703HCID 178476703, compoundYield 80%

Procedure

In the same manner as in Ref. Ex. 17, 1.59 g of 3,4 -diaminoquinoline (V-1) in 20 ml of acetic acid was treated with 1.9 g of methyl trichloroacetimidate to give 3.13 g (yield: 80%) of the titled compound (VIII-2).

Sources & evidence

ORD record: ord-ed8cfe6e2faf493caa54512627386ff6
Source dataset: uspto-grants-1990_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04940714

Reaction notes

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