2-Acetylthiophene → 2-Oxo-2-(thiophen-2-yl)acetaldehyde

Participants

Reaction Conditions

Reaction Steps

Al mixture of 27.5 g of selenium dioxide, 160 ml of dioxane and 5.5 ml of water was heated at 55° C. until solution was complete. A 31.54 g portion of 2-acetylthiophene was added and the mixture was refluxed for 4 hours, then cooled, filtered and evaporated under reduced pressure. The residue was distilled giving 24.5 g of 2-thiopheneglyoxylaldehyde.

Provenance & Evidence