反应详情

A mixture of 0.6 g of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.4 g of 2-(methoxymethyl)piperazine in 4 ml of pyridine was heated at 120°-130° C. under argon in a pressure bottle for 18 hours. The solvent was removed and the residue was chromatographed and the crude product triturated with methanol and ether, giving 370 mg of the desired product as white crystals, mp 215°-216° C.

1. temperaturewas heated at 120°-130° C. under argon in a pressure bottle for 18 hours
2. customThe solvent was removed
3. customthe residue was chromatographed
4. customthe crude product triturated with methanol and ether